Helper virus-mediated downregulation of transgene expression permits production of recalcitrant helper-dependent adenoviral vector
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چکیده
منابع مشابه
Helper virus-mediated downregulation of transgene expression permits production of recalcitrant helper-dependent adenoviral vector
Helper-dependent adenoviral vectors (HDAd) that express certain transgene products are impossible to produce because the transgene product is toxic to the producer cells, especially when made in large amounts during vector production. Downregulating transgene expression from the HDAd during vector production is a way to solve this problem. In this report, we show that this can be accomplished b...
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ژورنال
عنوان ژورنال: Molecular Therapy - Methods & Clinical Development
سال: 2016
ISSN: 2329-0501
DOI: 10.1038/mtm.2016.39